Major SNP (Q141K) Variant of Human ABC Transporter ABCG2 Undergoes Lysosomal and Proteasomal Degradations

Tomoka Furukawa, Kanako Wakabayashi, Ai Tamura, +4

Pharmaceutical Research

Molecular PhysiologyGenetic DisorderGeneticsPathogenesisProteasomal Degradations +9

Functional Validation of the Genetic Polymorphisms of Human ATP-Binding Cassette (ABC) Transporter ABCG2: Identification of Alleles That Are Defective in Porphyrin Transport

Ai Tamura, Masato Watanabe, Hikaru Saito, +4

Molecular Pharmacology

Re‐evaluation and functional classification of non‐synonymous single nucleotide polymorphisms of the human ATP‐binding cassette transporter <i>ABCG2</i>

Ai Tamura, Kanako Wakabayashi, Yuko Onishi, +6

Cancer Science

Disruption of N‐linked glycosylation enhances ubiquitin‐mediated proteasomal degradation of the human ATP‐binding cassette transporter ABCG2

Hiroshi Nakagawa, Kanako Wakabayashi‐Nakao, Ai Tamura, +3

FEBS Journal

Human Atp-binding CassetteGlycobiologyMolecular BiologyCancer BiologyN‐linked Glycosylation Enhances +18

Intramolecular Disulfide Bond Is a Critical Check Point Determining Degradative Fates of ATP-binding Cassette (ABC) Transporter ABCG2 Protein

Kanako Wakabayashi, Hiroshi Nakagawa, Ai Tamura, +4

Journal of Biological Chemistry

Protein SecretionMolecular BiologyCellular PhysiologyAbcg2 ProteinDisulfide Bond +19

In Vitro Evaluation of Photosensitivity Risk Related to Genetic Polymorphisms of Human ABC Transporter ABCG2 and Inhibition by Drugs

Ai Tamura, Yuko Onishi, Ran An, +9

Drug Metabolism and Pharmacokinetics

Ubiquitin-mediated proteasomal degradation of non-synonymous SNP variants of human ABC transporter ABCG2

Hiroshi Nakagawa, Ai Tamura, Kanako Wakabayashi, +7

Biochemical Journal

Non-synonymous Snp VariantsUbiquitin-mediated Proteasomal DegradationGeneticsImmunologyHuman Polymorphism +18

Nrf2-dependent induction of human ABC transporter ABCG2 and heme oxygenase-1 in HepG2 cells by photoactivation of porphyrins: biochemical implications for cancer cell response to photodynamic therapy.

Yuichiro Hagiya, Tatsuhiko Adachi, Shun‐ichiro Ogura, +6

PubMed

Visible LightHeme Oxygenase-1Redox BiologyOxidative StressSinglet Oxygen +16

Cushing Syndrome Due to ACTH-Secreting Pheochromocytoma, Aggravated by Glucocorticoid-Driven Positive-Feedback Loop

Ikki Sakuma, Seiichiro Higuchi, Masanori Fujimoto, +16

The Journal of Clinical Endocrinology & Metabolism

Nitensidine A, a guanidine alkaloid from Pterogyne nitens, is a novel substrate for human ABC transporter ABCB1

Yasuhiro Tajima, Hiroshi Nakagawa, Ai Tamura, +9

Phytomedicine

BiochemistryMedicineNatural SciencesGuanidine AlkaloidNitensidine A +6