Concepedia

Role of HLA-G and extracellular vesicles in renal cancer stem cell-induced inhibition of dendritic cell differentiation

Cristina Grange, Marta Tapparo, Stefania Tritta, Maria Chiara Deregibus, Antonino Battaglia, Paolo Gontero, Bruno Frea, Giovanni Camussi

BMC Cancer · 2015 · 126 citations · 32 references

DOIFull text

Open access

Abstract

In conclusion, the results of the present study indicate that renal cancer cells and in particular CSCs and derived EVs impair maturation of DCs and T cell immune response by a mechanism involving HLA-G.

References

32

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

Hadi Valadi, Karin M. Ekström, Apostolos Bossios et al. · Nature Cell Biology · 2007 · 12.6K citations

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Circulating microRNAs as stable blood-based markers for cancer detection

Patrick S. Mitchell, Rachael K. Parkin, Evan M. Kroh et al. · Proceedings of the National Academy of Sciences · 2008 · 7.9K citations · Full text

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

Johan Skog, Tom Würdinger, Sjoerd van Rijn et al. · Nature Cell Biology · 2008 · 4.9K citations

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Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis

Sónia A. Melo, Hikaru Sugimoto, Joyce T. O’Connell et al. · Cancer Cell · 2014 · 1.6K citations · Full text

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Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells

Xiao-Xia Jiang, Yi Zhang, Bing Liu et al. · Blood · 2005 · 1.3K citations · Full text