Concepedia

Low concentrations of 5-aza-2'-deoxycytidine induce breast cancer stem cell differentiation by triggering tumor suppressor gene expression

Phuc Van Pham, Nhan Lu-Chinh Phan, Van Ngu Trinh

OncoTargets and Therapy · 2015 · 19 citations · 64 references

DOIFull text

Open access

Abstract

DAC reduced breast cancer cell survival and induced differentiation through reexpression of tumor suppressor genes. These results indicate the potential of DAC in targeting specific chemotherapy-resistant cells within a tumor.

References

64

Prospective identification of tumorigenic breast cancer cells

Muhammad Al‐Hajj, Max S. Wicha, Adalberto Benito‐Hernández et al. · Proceedings of the National Academy of Sciences · 2003 · 10.3K citations · Full text

Cancer Stem Cells—Perspectives on Current Status and Future Directions: AACR Workshop on Cancer Stem Cells

Michael F. Clarke, John E. Dick, Peter B. Dirks et al. · Cancer Research · 2006 · 3.1K citations

, , +22

pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

Gregory J. Hannon, David Beach · Nature · 1994 · 1.9K citations

, , +7

let-7 Regulates Self Renewal and Tumorigenicity of Breast Cancer Cells

Fengyan Yu, Herui Yao, Pengcheng Zhu et al. · Cell · 2007 · 1.9K citations · Full text

, , +8

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

Steven J. Kuerbitz, Beverly Plunkett, William Walsh et al. · Proceedings of the National Academy of Sciences · 1992 · 1.9K citations · Full text

, , +15