Concepedia

MEK inhibitor GSK1120212-mediated radiosensitization of pancreatic cancer cells involves inhibition of DNA double-strand break repair pathways

Adriana Estrada‐Bernal, Moumita Chatterjee, S. Jaharul Haque, Linlin Yang, Meredith A. Morgan, Shweta Kotian, David J. Morrell, Arnab Chakravarti, Terence M. Williams

Cell Cycle · 2015 · 85 citations · 63 references

DOIFull text

Open access

Abstract

GSK212 confers radiosensitization to KRAS-driven PC cells by suppressing major DNA-DSB repair pathways. These data provide support for the combination of MEK1/2 inhibition and radiation in the treatment of PC.

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