<i>Hif1a</i> Deletion Reveals Pro-Neoplastic Function of B Cells in Pancreatic Neoplasia

Abstract

We show here that pancreas-specific Hif1a deletion promotes PDAC initiation, coincident with increased intrapancreatic accumulation of B cells, and that B-cell depletion suppresses pancreatic tumorigenesis. We therefore demonstrate a protective role for HIF1α in pancreatic cancer initiation and uncover a previously unrecognized function of B cells.