Antihyperlipidemic activity of Bauhinia purpurea extracts in hypercholesterolemic albino rats

Abstract

Bauhinia purpurea is a flowering plant. Several species of this plant are known to possess pharmacological activities. It is a less explored plant, but it possesses phytoconstituents such as flavonoids which are purported to exhibit wide pharmacological activities. In the present study the ethanol extract of unripe pods and leaves of Bauhinia purpurea was evaluated for antihyperlipidemic activity in cholesterol high fat diet (CHFD) induced hyperlipidemia. Hyperlipidemia was induced by giving high cholesterol diet in standard rat chow diet for thirty days. The groups of rats selected for the study were treated with atorvastatin, ethanol extract of unripe pods and ethanol extract of leaves daily for the whole period. Changes in body weight and the analysis of serum lipids were carried out at the end of the study. There was a marked decrease in body weight, total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL) and very low density lipoprotein (VLDL) levels. Also there was a significant increase in high density lipoprotein levels after the treatment with Bauhinia purpurea extracts. Ethanol extract of leaves showed a marked effect over body weight reduction and also had a significant effect on the lipoprotein profile. There is a lowered atherogenic index, TC: HDL-c and LDL: HDL-c ratios in the extract treated groups. The present work indicated that Bauhinia purpurea extracts significantly suppressed the CHFD induced hyperlipidemia in rats, suggesting the antihyperlipidemic and antiatherogenic potential of the extracts. Further studies are needed to characterize the phytoconstituents responsible for the study.