American Journal of Tropical Medicine and Hygiene · 2005 · 57 citations · 23 references
MedicineGeneticsMolecular GeneticsMedical GeneticsPharmacogeneticsPharmacogenomicsDisease Resistance GeneticsDrug ResistanceDrug Resistance GenomicsMalariaMolecular Basis Of ResistanceResistance GenesAntimalarial Drug Resistance SurveillanceGene Copy Number AnalysisGenetic Markers Of ResistanceMalaria ResistanceMalaria SurveillancePlasmodium FalciparumProspective Cohort DataSingle-nucleotide Polymorphisms
Molecular markers have been proposed as a method of monitoring malaria drug resistance and could potentially be used to prolong the life span of antimalarial drugs. Single nucleotide polymorphisms (SNPs) in the Plasmodium falciparum gene pfmdr1 and increased gene copy number have been associated with in vitro drug resistance but have not been well studied in vivo. In a prospective cohort study of malaria patients receiving mefloquine treatment on the Thai-Myanmar border, there was no significant association between either pfmdr1 SNPs or in vitro drug sensitivity and mefloquine resistance in vivo. Increased pfmdr1 gene copy number was significantly associated with recrudescence (relative risk 2.30, 95% CI 1.27-4.15). pfmdr1 gene copy number may be a useful surveillance tool for mefloquine-resistant falciparum malaria in Thailand.
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Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number
Ric N. Price, Anne‐Catrin Uhlemann, Alan Brockman et al. · The Lancet · 2004 · 839 citations
Alan F. Cowman, Denise Galatis, Jennifer K. Thompson · Proceedings of the National Academy of Sciences · 1994 · 390 citations