Increased systemic exposure to rosuvastatin in Asian subjects residing in the United States compared with Caucasian subjects

Abstract

n=26 n=27 n=26 n=26 n=26 n=27 n=26 AUC (0-t) (ng.h/mL) Gmean (95% CI) 14.5 (10.4-11.7) (8.3-20.5) (5.5-17.5) (7.3-19.9) (7.1-15.6) (6.7-22.0) (5.0-21.0) (8.4-22.5) Ratio (90% CI) ‡ 0.76 0.82 0.74 0.79 0.75 0.80 0.70 (0.66-0.87) (0.70-0.96) (0.62-0.87) (0.67-0.93) (0.63-0.88) (0.68-0.94) (0.59-0.82) ‡ Ratio of Asian subgroup to Caucasian group (based on Gmean data) § t1/2 λz was not measured in all subjects: Pooled Asian (n=93); Chinese (n=21), Filipino (n=17), Asian-Indian (n=19); Korean (n=17); Vietnamese (n=19); Japanese (n=19) and Caucasian (n=14)