Concepedia

Increased sensitivity to platinum drugs of cancer cells with acquired resistance to trabectedin

Benedetta Colmegna, Sarah Uboldi, Roberta Frapolli, Simonetta Andrea Licandro, Nicolò Panini, Carlos M. Galmarini, Nadia Badri, Victoria J. Spanswick, John P. Bingham, Konstantinos Kiakos,

British Journal of Cancer · 2015 · 43 citations · 32 references

DOIFull text

Open access

Abstract

Our finding that resistance to trabectedin is associated with the loss of NER function, with a consequent increased sensitivity to platinum drugs, provides the rational for sequential use of these drugs in patients who have acquired resistance to trabectedin.

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