Chemokines fluctuate in the progression of primary breast cancer.

Abstract

The correlation analysis indicated the great crosstalk between chemokines and receptors in the course of primary breast cancer; Ki67 expression was associated with CXCL5 and CXCL7 concentration; tumor size was associated with CXCL8 concentration; and the correlation analysis between clinico-pathological characters of patients showed that pathological diagnosis was correlated with tumor size, relapse risk and Ki67 expression; nuclear grades was correlated with LN metastasis, ER status, PR status and the breast cancer genotype; LN metastasis was correlated with relapse risk. Our findings clearly indicated for the first time that the fluctuations of chemokines and receptors contributed to the evolving of primary breast cancer.