Concepedia

Novel substituted 4-phenyl-[1,3]dioxanes: potent and selective orexin receptor 2 (OX2R) antagonists

Laura C. McAtee, Steven W. Sutton, Dale A. Rudolph, Xiaobing Li, Leah Aluisio, Victor K. Phuong, Curt A. Dvorak, Timothy W. Lovenberg, Nicholas I. Carruthers, Todd K. Jones

Bioorganic & Medicinal Chemistry Letters · 2004 · 78 citations · 18 references

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18

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

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The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity

Luı́s de Lecea, Thomas S. Kilduff, Christelle Peyron et al. · Proceedings of the National Academy of Sciences · 1998 · 3.9K citations

, , +15

Narcolepsy in orexin Knockout Mice

Richard M. Chemelli, Jon T. Willie, Christopher M. Sinton et al. · Cell · 1999 · 3.1K citations · Full text

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The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene

Ling Lin, Juliette Faraco, Robin Li et al. · Cell · 1999 · 2.6K citations · Full text

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Complex HLA-DR and -DQ Interactions Confer Risk of Narcolepsy-Cataplexy in Three Ethnic Groups

Emmanuel Mignot, Ling Lin, William M. Rogers et al. · The American Journal of Human Genetics · 2001 · 598 citations · Full text

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