Concepedia

Asymmetric Synthesis of <i>trans</i>-2,5-Disubstituted Pyrrolidines from Enantiopure Homoallylic Amines. Synthesis of Pyrrolidine (−)-197B

Franklin A. Davis, Minsoo Song, Alexander Augustine

The Journal of Organic Chemistry · 2006 · 66 citations · 38 references

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Abstract

Iodocyclization of sulfinimine-derived enantiopure homoallylic sulfonamides affords trans-2,5-disubstituted 3-iodopyrrolidines and represents valuable methodology for the asymmetric synthesis of this important heterocyclic ring system.

References

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<i>N-tert</i>-Butanesulfinyl Imines:  Versatile Intermediates for the Asymmetric Synthesis of Amines

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Direct Organocatalytic Asymmetric α-Chlorination of Aldehydes

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