Concepedia

Discovery of trans-3,4′-bispyridinylethylenes as potent and novel inhibitors of protein kinase B (PKB/Akt) for the treatment of cancer: Synthesis and biological evaluation

Qun Li, Tongmei Li, Gui‐Dong Zhu, Jianchun Gong, Akiyo Claibone, Chris I. Dalton, Yan Luo, Eric F. Johnson, Yan Shi, Xuesong Liu,

Bioorganic & Medicinal Chemistry Letters · 2006 · 32 citations · 12 references

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12

Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification.

Steven K. Hanks, Tony Hunter · PubMed · 1995 · 2.5K citations

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The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification <sup>1</sup>

Steven K. Hanks, Tony Hunter · The FASEB Journal · 1995 · 2.3K citations

, , +16

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA.

Jin Q. Cheng, Bruce Ruggeri, Willemijn M. Klein et al. · Proceedings of the National Academy of Sciences · 1996 · 793 citations

, , +17

Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors

Craig W. Lindsley, Zhijian Zhao, William Leister et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 501 citations · Full text

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Akt and Bcl-xL Promote Growth Factor-independent Survival through Distinct Effects on Mitochondrial Physiology

David R. Plas, Sunit Talapatra, Aimee L. Edinger et al. · Journal of Biological Chemistry · 2001 · 302 citations · Full text

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