Concepedia

2-{2-[3-(Pyridin-3-yloxy)phenyl]-2H-tetrazol-5-yl}pyridine: a highly potent, orally active, metabotropic glutamate subtype 5 (mGlu5) receptor antagonist

Dehua Huang, Steve F. Poon, Deborah F. Chapman, Janice Chung, Merryl Cramer, Thomas S. Reger, Jeffrey Roppe, Lida Tehrani, Nicholas D. P. Cosford, Nicholas D. Smith

Bioorganic & Medicinal Chemistry Letters · 2004 · 29 citations · 15 references

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15

Altered synaptic plasticity in a mouse model of fragile X mental retardation

Kimberly M. Huber, Sean Gallagher, Stephen T. Warren et al. · Proceedings of the National Academy of Sciences · 2002 · 1.3K citations

, , +17

Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice

Cristiano Chiamulera, Mark P. Epping-Jordan, Alessandro Zocchi et al. · Nature Neuroscience · 2001 · 549 citations

, , +14

3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]- pyridine:  A Potent and Highly Selective Metabotropic Glutamate Subtype 5 Receptor Antagonist with Anxiolytic Activity

Nicholas D. P. Cosford, Lida Tehrani, Jeffrey Roppe et al. · Journal of Medicinal Chemistry · 2002 · 400 citations · Full text

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Potential anxiolytic‐ and antidepressant‐like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist

E Tatarczyńska, Aleksandra Kłodzińska, E Chojnacka-Wójcik et al. · British Journal of Pharmacology · 2001 · 309 citations · Full text

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Anxiolytic-Like Effects of the Prototypical Metabotropic Glutamate Receptor 5 Antagonist 2-Methyl-6-(phenylethynyl)pyridine in Rodents

Will Spooren, A. Vassout, H.C. Neijt et al. · Journal of Pharmacology and Experimental Therapeutics · 2000 · 266 citations

, , +15