Concepedia

Platelet-Associated Matrix Metalloproteinases Regulate Thrombus Formation and Exert Local Collagenolytic Activity

Tom G. Mastenbroek, Marion A.H. Feijge, Romy Kremers, Marion T.J. van den Bosch, Frauke Swieringa, Lies De Groef, Lieve Moons, Cavan Bennett, Cédric Ghevaert, Jason L. Johnson,

Arteriosclerosis Thrombosis and Vascular Biology · 2015 · 52 citations · 28 references

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Abstract

Platelet-associated MMP-1, MMP-2, MMP-9, and MMP-14 differentially modulate acute thrombus formation and at later time points limit thrombus formation by exerting collagenolytic activity.

References

28

MT1-MMP-Deficient Mice Develop Dwarfism, Osteopenia, Arthritis, and Connective Tissue Disease due to Inadequate Collagen Turnover

Kenn Holmbeck, Paolo Bianco, John J. Caterina et al. · Cell · 1999 · 1.3K citations · Full text

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CD40L stabilizes arterial thrombi by a β3 integrin–dependent mechanism

Patrick André, K. S. Srinivasa Prasad, Cécile V. Denis et al. · Nature Medicine · 2002 · 724 citations

, , +5

Unaltered Secretion of β-Amyloid Precursor Protein in Gelatinase A (Matrix Metalloproteinase 2)-deficient Mice

Takeshi Itoh, Toshio Ikeda, Hiroshi Gomi et al. · Journal of Biological Chemistry · 1997 · 352 citations · Full text

Release of gelatinase A during platelet activation mediates aggregation

Grzegorz Sawicki, Eduardo Salas, Jesus Murat et al. · Nature · 1997 · 347 citations

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Platelet Matrix Metalloprotease-1 Mediates Thrombogenesis by Activating PAR1 at a Cryptic Ligand Site

Vishal Trivedi, Adrienne Boire, Boris Tchernychev et al. · Cell · 2009 · 242 citations · Full text

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