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5-Lipoxygenase-activating protein inhibitors. Part 2: 3-{5-((S)-1-Acetyl-2,3-dihydro-1H-indol-2-ylmethoxy)-3-tert-butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-1H-indol-2-yl}-2,2-dimethyl-propionic acid (AM679)—A potent FLAP inhibitor

Nicholas Stock, Christopher Baccei, Gretchen Bain, Alex Broadhead, Charles W. Chapman, Janice Darlington, Christopher D. King, Catherine Lee, Yiwei Li, Daniel S. Lorrain,

Bioorganic & Medicinal Chemistry Letters · 2009 · 21 citations · 14 references

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References

14

Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis

Richard A. F. Dixon, Ronald E. Diehl, Evan E. Opas et al. · Nature · 1990 · 776 citations

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Characterization of the Human Cysteinyl Leukotriene 2 Receptor

Christopher E. Heise, Brian F. O’Dowd, David J. Figueroa et al. · Journal of Biological Chemistry · 2000 · 663 citations · Full text

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The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl‐leukotrienes receptor

Paolo Ciana, Marta Fumagalli, Maria Letizia Trincavelli et al. · The EMBO Journal · 2006 · 439 citations · Full text

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Crystal Structure of Inhibitor-Bound Human 5-Lipoxygenase-Activating Protein

Andrew D. Ferguson, Brian M. McKeever, Shihua Xu et al. · Science · 2007 · 225 citations

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The effect of MK-0591, a novel 5-lipoxygenase activating protein inhibitor, on leukotriene biosynthesis and allergen-induced airway responses in asthmatic subjects in vivo

Zuzana Diamant, Mieke Timmers, H. van der Veen et al. · Journal of Allergy and Clinical Immunology · 1995 · 157 citations

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