Fleming−Tamao Oxidation and Masked Hydroxyl Functionality:  Total Synthesis of (+)-Pramanicin and Structural Elucidation of the Antifungal Natural Product (−)-Pramanicin

Anthony G. M. Barrett, John C. Head, Marie L. Smith, +3

The Journal of Organic Chemistry

Antifungal AgentBioorganic ChemistryDerivativesBiochemistryNatural Sciences +8

Glucuronidation of carboxylic acid containing compounds by UDP-glucuronosyltransferase isoforms

Kayo Sakaguchi, Mitchell Green, Nicholas Stock, +3

Archives of Biochemistry and Biophysics

BiosynthesisBioorganic ChemistryBiotransformationBiochemistryAldehyde Dehydrogenase +4

Pharmacological Blockade of the DP2 Receptor Inhibits Cigarette Smoke-Induced Inflammation, Mucus Cell Metaplasia, and Epithelial Hyperplasia in the Mouse Lung

Karin J. Stebbins, Alex Broadhead, Christopher Baccei, +14

Journal of Pharmacology and Experimental Therapeutics

5-Lipoxygenase-Activating Protein (FLAP) Inhibitors. Part 4: Development of 3-[3- <i>tert</i> -Butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1 <i>H</i> -indol-2-yl]-2,2-dimethylpropionic Acid (AM803), a Potent, Oral, Once Daily FLAP Inhibitor

Nicholas Stock, Gretchen Bain, Jasmine Zunic, +17

Journal of Medicinal Chemistry

Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine model of allergic rhinitis

Brian A. Stearns, Christopher Baccei, Gretchen Bain, +15

Bioorganic & Medicinal Chemistry Letters

InflammationAllergyAllergy MedicineMedicineMurine Model +8

5-Lipoxygenase-Activating Protein Inhibitors: Development of 3-[3-<i>tert</i>-Butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1<i>H</i>-indol-2-yl]-2,2-dimethyl-propionic Acid (AM103)

John H. Hutchinson, Yiwei Li, Jeannie M. Arruda, +14

Journal of Medicinal Chemistry

A Selective Novel Peroxisome Proliferator-Activated Receptor (PPAR)-α Antagonist Induces Apoptosis and Inhibits Proliferation of CLL Cells In Vitro and In Vivo

Davorka Messmer, Kymmy Lorrain, Karin J. Stebbins, +11

Molecular Medicine

ApoptosisCell DeathPharmacotherapyMetabolic RemodelingCancer Biology +19

In vitro and in vivo pharmacology of NXT629, a novel and selective PPARα antagonist

Karin J. Stebbins, Alex Broadhead, Geraldine Cabrera, +9

European Journal of Pharmacology

Molecular PharmacologySelective Pparα AntagonistMedicinePhysiologyMechanism Of Action +8

Pharmacology of AM803, a novel selective five-lipoxygenase-activating protein (FLAP) inhibitor in rodent models of acute inflammation

Daniel S. Lorrain, Gretchen Bain, Lucia Correa, +15

European Journal of Pharmacology

InflammationAnti-inflammatoryAcute InflammationMedicineLipid Peroxidation +8

The geminal dimethyl analogue of Flurbiprofen as a novel Aβ42 inhibitor and potential Alzheimer’s disease modifying agent

Nicholas Stock, Benito Muñoz, Jonathan D.J. Wrigley, +9

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyNeurodegenerative DiseasesAlzheimer's DiseaseNovel Aβ42 InhibitorMedicine +9