Identification of an anti-inflammatory protein from <i>Faecalibacterium prausnitzii</i> , a commensal bacterium deficient in Crohn’s disease

Abstract

A 15 kDa protein with anti-inflammatory properties is produced by F. prausnitzii, a commensal bacterium involved in CD pathogenesis. This protein is able to inhibit the NF-κB pathway in intestinal epithelial cells and to prevent colitis in an animal model.