Convection enhanced delivery of IL13-PE38QQR for treatment of recurrent malignant glioma: presentation of interim findings from ongoing phase 1 studies

Convection-enhanced delivery of macromolecules in the brain.

R. Hunt Bobo, Douglas W. Laske, Aytaç Akbaşak et al. · Proceedings of the National Academy of Sciences · 1994 · 1.4K citations

Pharmacy, Neuroscience, Pharmaceutics +16

Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas

Henry Brem, Steven Piantadosi, P. C. Burger et al. · The Lancet · 1995 · 1.4K citations · Full text

Pharmacy, Oncology, Surgery +16

A phase II study of temozolomide vs. procarbazine in patients with glioblastoma multiforme at first relapse

W.K. Alfred Yung, Robert E. Albright, Jeffrey J. Olson et al. · British Journal of Cancer · 2000 · 939 citations · Full text

Medicine, Oncology, Pharmacology +17

Multicenter Phase II Trial of Temozolomide in Patients With Anaplastic Astrocytoma or Anaplastic Oligoastrocytoma at First Relapse

W.K. Alfred Yung, Michael D. Prados, Ricardo Yayá et al. · Journal of Clinical Oncology · 1999 · 763 citations

Medicine, Oncology, Pharmacotherapy +17

Tumor regression with regional distribution of the targeted toxin TF-CRM107 in patients with malignant brain tumors

Douglas W. Laske, Richard J. Youle, Edward H. Oldfield · Nature Medicine · 1997 · 530 citations

Medicine, Neuroscience, Oncology +10