Remarkable Chemo-, Regio-, and Enantioselectivity in Lipase-Catalyzed Hydrolysis: Efficient Resolution of (±)-<i>threo</i>-Ethyl 3-(4-Methoxyphenyl)-2,3-diacetoxypropionate Leading to Chiral Intermediates of (+)-Diltiazem

Abstract

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTRemarkable Chemo-, Regio-, and Enantioselectivity in Lipase-Catalyzed Hydrolysis: Efficient Resolution of (±)-threo-Ethyl 3-(4-Methoxyphenyl)-2,3-diacetoxypropionate Leading to Chiral Intermediates of (+)-Diltiazem†Shrivallabh B. Desai, Narshinha P. Argade, and Krishna N. GaneshView Author Information Division of Organic Chemistry (Synthesis), National Chemical Laboratory, Pune 411008, India Cite this: J. Org. Chem. 1996, 61, 19, 6730–6732Publication Date (Web):September 20, 1996Publication History Received7 May 1996Published online20 September 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/jo960835lhttps://doi.org/10.1021/jo960835lbrief-reportACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views356Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Diols,Hydrolysis,Organic compounds,Peptides and proteins,Reaction products Get e-Alerts