Direct mono-phosphorylation of 1,3-diols. A synthesis of FTY720-phosphate

Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists

Suzanne Mandala, Richard Hajdu, James D. Bergstrom et al. · Science · 2002 · 1.7K citations

Life Sciences, Immunology, Pharmacology +17

The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors

Volker Brinkmann, Michael D. Davis, Christopher E. Heise et al. · Journal of Biological Chemistry · 2002 · 1.5K citations · Full text

Medicine, Immunology, Pharmacology +17

FTY720, a Novel Immunosuppressant, Induces Sequestration of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing in Rats. I. FTY720 Selectively Decreases the Number of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing

Kenji Chiba, Yoshiki Yanagawa, Yumi Masubuchi et al. · The Journal of Immunology · 1998 · 596 citations

Life Sciences, Immunology, Pharmacology +15

Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1,3-propanediols: Discovery of a novel immunosuppressant, FTY720

Kunitomo Adachi, Toshiyuki Kohara, Noriyoshi Nakao et al. · Bioorganic & Medicinal Chemistry Letters · 1995 · 308 citations

Pharmacy, Medicinal Chemistry, Pharmacology +14

Synthesis and Immunosuppressive Activity of 2-Substituted 2-Aminopropane-1,3-diols and 2-Aminoethanols

Masatoshi Kiuchi, Kunitomo Adachi, Toshiyuki Kohara et al. · Journal of Medicinal Chemistry · 2000 · 218 citations

Pharmacy, Immunology, Medicinal Chemistry +13