New efficient synthesis of isoquinoline-1,3(2H,4H)-diones and isoindolin-1-ones via sequential Ugi/cyclization reaction

Recent application of isocyanides in synthesis of heterocycles

Samahe Sadjadi, Majid M. Heravı · Tetrahedron · 2011 · 168 citations

Natural Sciences, Chemistry, Medicinal Chemistry +12

Isoindolinone Inhibitors of the Murine Double Minute 2 (MDM2)-p53 Protein−Protein Interaction: Structure−Activity Studies Leading to Improved Potency

Ian R. Hardcastle, Junfeng Liu, Eric Valeur et al. · Journal of Medicinal Chemistry · 2011 · 149 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +7

Syntheses of Substituted 3-Methyleneisoindolin-1-ones By a Palladium-Catalyzed Sonogashira Coupling−Carbonylation−Hydroamination Sequence in Phosphonium Salt-Based Ionic liquids

Hong Cao, Laura McNamee, Howard Alper · Organic Letters · 2008 · 146 citations

Natural Sciences, Chemistry, Catalysis +8

Catalytic Three‐Component Ugi Reaction

Subhas Chandra Pan, Benjamin List · Angewandte Chemie International Edition · 2008 · 141 citations

Natural Sciences, Chemistry, Medicinal Chemistry +15

Magnesium Chelating 2-Hydroxyisoquinoline-1,3(2<i>H</i>,4<i>H</i>)-diones, as Inhibitors of HIV-1 Integrase and/or the HIV-1 Reverse Transcriptase Ribonuclease H Domain: Discovery of a Novel Selective Inhibitor of the Ribonuclease H Function

Muriel Billamboz, Fabrice Bailly, Cédric Lion et al. · Journal of Medicinal Chemistry · 2011 · 135 citations · Full text

Life Sciences, Chemistry, Medicinal Chemistry +14