Amplification of<i>pvmdr1</i>Associated with Multidrug‐Resistant<i>Plasmodium vivax</i>

Abstract

Amplification of pvmdr1 and single-nucleotide polymorphisms are correlated with susceptibility of P. vivax to multiple antimalarial drugs. Chloroquine and mefloquine appear to exert competitive evolutionary pressure on pvmdr1, similar to that observed with pfmdr1 in Plasmodium falciparum.