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Effects of Valproic Acid Derivatives on Inositol Trisphosphate Depletion, Teratogenicity, Glycogen Synthase Kinase-3β Inhibition, and Viral Replication: A Screening Approach for New Bipolar Disorder Drugs Derived from the Valproic Acid Core Structure

Britta J. Eickholt, Greg J. Towers, W.J. Ryves, Daniel Eikel, Kathryn Adley, Laura M. J. Ylinen, Neil Chadborn, Adrian J. Harwood, Heinz Nau, Robin S. B. Williams

Molecular Pharmacology · 2005 · 70 citations · 35 references

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35

A molecular mechanism for the effect of lithium on development.

Peter S. Klein, Douglas A. Melton · Proceedings of the National Academy of Sciences · 1996 · 2.3K citations

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Histone Deacetylase Is a Direct Target of Valproic Acid, a Potent Anticonvulsant, Mood Stabilizer, and Teratogen

Christopher J. Phiel, Fang Zhang, Eric Yi‐Hsiu Huang et al. · Journal of Biological Chemistry · 2001 · 1.7K citations · Full text

, , +17

Lithium inhibits glycogen synthase kinase-3 activity and mimics Wingless signalling in intact cells

Vuk Stambolic, Laurent Ruel, James R. Woodgett · Current Biology · 1996 · 1.3K citations · Full text

, , +10

A common mechanism of action for three mood-stabilizing drugs

Robin S. B. Williams, Lili Cheng, Anne W. Mudge et al. · Nature · 2002 · 625 citations

, , +9

Repression by Ume6 Involves Recruitment of a Complex Containing Sin3 Corepressor and Rpd3 Histone Deacetylase to Target Promoters

David Kadosh, Kevin Struhl · Cell · 1997 · 546 citations · Full text

, , +16