Concepedia

Hypoxic Epithelial Necrosis Triggers Neutrophilic Inflammation via IL-1 Receptor Signaling in Cystic Fibrosis Lung Disease

Benedikt Fritzsching, Zhe Zhou-Suckow, Joanna Trojanek, Susanne Schubert, Jolanthe Schatterny, Stephanie Hirtz, Raman Agrawal, Thomas Muley, Nicolas Kahn, Carsten Sticht,

American Journal of Respiratory and Critical Care Medicine · 2015 · 105 citations · 47 references

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Abstract

Our results support an important role of hypoxic epithelial necrosis in the pathogenesis of neutrophilic inflammation independent of bacterial infection and suggest IL-1R as a novel target for antiinflammatory therapy in CF and potentially other mucoobstructive airway diseases.

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