Endogenous Orphanin FQ/Nociceptin Is Involved in the Development of Morphine Tolerance

Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor

Jean‐Claude Meunier, Catherine Mollereau, Lawrence Toll et al. · Nature · 1995 · 1.9K citations

Medicine, Medicinal Chemistry, Pharmacology +14

Orphanin FQ: A Neuropeptide That Activates an Opioidlike G Protein-Coupled Receptor

Rainer K. Reinscheid, Hans‐Peter Nothacker, Anne Bourson et al. · Science · 1995 · 1.8K citations

Medicine, Neuroscience, Pharmacology +17

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene

Hans W. D. Matthes, Rafaël Maldonado, Frédéric Simonin et al. · Nature · 1996 · 1.7K citations

Medicine, Neuroscience, Pharmacology +17

Inhibition of Morphine Tolerance and Dependence by the NMDA Receptor Antagonist MK-801

Keith A. Trujillo, Huda Akil · Science · 1991 · 1.2K citations

Medicine, Neuroscience, Pharmacology +17

Functional Dissociation of μ Opioid Receptor Signaling and Endocytosis

Jennifer L. Whistler, Huai-hu Chuang, Peter C. Chu et al. · Neuron · 1999 · 417 citations · Full text

Life Sciences, Cell Biology, Neuroscience +11