Concepedia

Mesenchymal Stem Cells Maintain Blood-Brain Barrier Integrity by Inhibiting Aquaporin-4 Upregulation After Cerebral Ischemia

Guanghui Tang, Zhijun Zhang, Yifan Lu, Yang Wang, Jun Huang, Yaning Li, Xiang Gu, Yongting Wang, Guo‐Yuan Yang

Stem Cells · 2014 · 144 citations · 41 references

DOIFull text

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Abstract

MSCs protected BBB integrity by reducing the apoptosis of astrocytes after ischemic attack, which was due to the attenuation of inflammatory response and downregulation of aquaporin-4 expression via p38 signaling pathway.

References

41

Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of bone

Edwin M. Horwitz, Patricia Gordon, Winston K. K. Koo et al. · Proceedings of the National Academy of Sciences · 2002 · 1.6K citations · Full text

, , +21

Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke

Geoffrey T. Manley, Miki Fujimura, Tonghui Ma et al. · Nature Medicine · 2000 · 1.5K citations

, , +13

Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects

Luis A. Ortiz, Frederica Gambelli, C.E. McBride et al. · Proceedings of the National Academy of Sciences · 2003 · 1.5K citations · Full text

Specialized Membrane Domains for Water Transport in Glial Cells: High-Resolution Immunogold Cytochemistry of Aquaporin-4 in Rat Brain

Søren Nielsen, Erlend A. Nagelhus, Mahmood Amiry‐Moghaddam et al. · Journal of Neuroscience · 1997 · 1.4K citations · Full text

, , +19

Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy

Emanuela Zappia, Simona Casazza, Enrico Pedemonte et al. · Blood · 2005 · 1.4K citations · Full text