Polish Journal of Environmental Studies · 2000 · 14 citations · 14 references
Veterinary MedicineToxicologyVeterinary ToxicologyDevelopmental ToxicologyHeavy Metal ToxicologyReproductive ToxicologyCadmium ToxicologyHeavy Metal Reproductive ToxicityMetal ToxicityPrenatal ToxicitySelenium ToxicitySelenium ToxicologyCadmium Developmental ToxicityDevelopmental Exposure To Heavy MetalsDevelopmental Toxicity Of SeleniumHeavy Metal Developmental ToxicityHeavy Metal Placental ToxicityPrenatal Heavy Metal ExposureReproductive Toxicity Of SeleniumSelenium Reproductive Effects
The present studies were carried out in order to assess the protective effects of selenium against cadmium toxicity in pregnant hamsters. On the 8 th day of gestation the females were dosed subcutaneously either with cadmium or with cadmium and selenium in the following doses (mg per kilogram of body weight): 0, 1 Cd, 1 Cd + 1 Se, 2 Cd, 2 Cd + 2 Se. In groups treated with cadmium decreased litter size, increased postimplantation losses, reduced foetal weight, elevated percentage of resorptions and increased incidence of malformations were noted. Injection of Cd and Se resulted in significantly lower embryo- and foetotoxic indices. Selenium also reduced Cd concentrations in maternal tissues but not in the placenta nor in the foetuses.
14