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Macrocyclic BACE-1 inhibitors acutely reduce Aβ in brain after po application

Andreas Lerchner, Rainer Machauer, Claudia Betschart, Siem J. Veenstra, Heinrich Rueeger, Clive McCarthy, Marina Tintelnot‐Blomley, Anne-Lise Jaton, Sabine Rabe, Sandrine Desrayaud,

Bioorganic & Medicinal Chemistry Letters · 2009 · 58 citations · 14 references

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14

Increased ring closing metathesis activity of ruthenium-based olefin metathesis catalysts coordinated with imidazolin-2-ylidene ligands

Matthias Scholl, Tina M. Trnka, John P. Morgan et al. · Tetrahedron Letters · 1999 · 898 citations

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Structure of the Protease Domain of Memapsin 2 (β-Secretase) Complexed with Inhibitor

Hong Lin, Gerald Koelsch, Xinli Lin et al. · Science · 2000 · 706 citations

, , +17

In vitro models for the blood–brain barrier

Per Garberg, Marguerite Ball, Natalia Borg et al. · Toxicology in Vitro · 2004 · 395 citations

, , +14

Evaluation of the MDR-MDCK cell line as a permeability screen for the blood–brain barrier

Qing Wang, Joseph Rager, Kathryn E. Weinstein et al. · International Journal of Pharmaceutics · 2004 · 345 citations

, , +9

Structure-Based Design:  Potent Inhibitors of Human Brain Memapsin 2 (β-Secretase)

Arun K. Ghosh, Geoffrey Bilcer, Cynthia Harwood et al. · Journal of Medicinal Chemistry · 2001 · 224 citations · Full text

, , +17