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Hybrid αγ Polypeptides: Structural Characterization of a C<sub>12</sub>/C<sub>10</sub> Helix with Alternating Hydrogen‐Bond Polarity
38
Citations
15
References
2008
Year
Crystal StructureStructural CharacterizationDifferent TwistHybrid αγ PolypeptidesProtein AssemblyBiochemistryRegular Mixed HelixNatural SciencesMedicineHydrogen BondMolecular BiologyPeptide TherapeuticPeptide SynthesisPeptide ScienceMolecular BiophysicsAlternating Hydrogen‐bond PolarityMolecular ModelingStructural Biology
A different twist: A mixed C12/C10 helix with alternating hydrogen-bond directionality has been observed in the crystal structure of the hybrid αγ peptide Boc-Leu-Gpn-Leu-Aib-OMe (see structure; Boc: tert-butoxycarbonyl; Leu: leucine; Gpn: 1-(aminomethyl)cyclohexaneacetic acid (gabapentin); Aib: aminoisobutyric acid). The structure may be generalized to a regular mixed helix.
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