Concepedia

Hybrid αγ Polypeptides: Structural Characterization of a C<sub>12</sub>/C<sub>10</sub> Helix with Alternating Hydrogen‐Bond Polarity

Prema G. Vasudev, Sunanda Chatterjee, Kuppanna Ananda, N. Shamala, Padmanabhan Balaram

Angewandte Chemie International Edition · 2008 · 38 citations · 15 references

DOI

Concepts

Abstract

A different twist: A mixed C12/C10 helix with alternating hydrogen-bond directionality has been observed in the crystal structure of the hybrid αγ peptide Boc-Leu-Gpn-Leu-Aib-OMe (see structure; Boc: tert-butoxycarbonyl; Leu: leucine; Gpn: 1-(aminomethyl)cyclohexaneacetic acid (gabapentin); Aib: aminoisobutyric acid). The structure may be generalized to a regular mixed helix.

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