Concepedia

Alpha-helix Formation

Alpha-Helix Formation is a structural folding process in which a polypeptide chain twists into a right-handed helical conformation stabilized by intramolecular hydrogen bonds between the backbone carbonyl oxygen of residue *i* and the amide hydrogen of residue *i*+4, representing a fundamental secondary structure motif in proteins.

2.3K

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156.3K

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7.5K

Authors

1.5K

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Publications per year

2017–2026

126

Parents

Publications

2.3K

Determination of the helix and β form of proteins in aqueous solution by circular dichroism

Yee-Hsiung Chen, Jen Tsi Yang, Kue Hung Chau · Biochemistry · 1974 · 2.1K citations

, , +17

Pathways to a Protein Folding Intermediate Observed in a 1-Microsecond Simulation in Aqueous Solution

Yong Duan, Peter A. Kollman · Science · 1998 · 1.3K citations

, , +17

A Thermodynamic Scale for the Helix-Forming Tendencies of the Commonly Occurring Amino Acids

Karyn T. O’Neil, William F. DeGrado · Science · 1990 · 1.2K citations

, , +17

Helix stabilization by Glu-...Lys+ salt bridges in short peptides of de novo design.

Susan Marqusee, Robert L. Baldwin · Proceedings of the National Academy of Sciences · 1987 · 956 citations · Full text

, , +17

Optimized Molecular Dynamics Force Fields Applied to the Helix−Coil Transition of Polypeptides

Robert B. Best, Gerhard Hummer · The Journal of Physical Chemistry B · 2009 · 914 citations · Full text

, , +16

1–5 of 2.3K

Authors

7.5K

  1. RL
    Robert L. Baldwin

    Stanford University, United States

    30 publications · 7.2K citations

    28

    h-index

  2. SH
    Samuel H. Gellman

    University of Wisconsin–Madison, United States

    29 publications · 3.2K citations

    24

    h-index

  3. CT
    Claudio Toniolo

    University of Padua, Italy

    28 publications · 1.6K citations

    22

    h-index

  4. NR
    Neville R. Kallenbach

    New York University, United States

    24 publications · 2.8K citations

    22

    h-index

  5. IH
    Ivan Huc

    Institut Européen de Chimie et Biologie, France

    21 publications · 2.1K citations

    20

    h-index

1–5 of 7.5K

Institutions

1.5K

  1. Centre National de la Recherche Scientifique

    Paris, France

    40 h-index

    494 publications

    24.6K citations

  2. Stanford University

    Stanford, United States

    31 h-index

    87 publications

    19.7K citations

  3. National Institutes of Health

    Bethesda, United States

    30 h-index

    97 publications

    10.1K citations

  4. New York University

    New York, United States

    29 h-index

    99 publications

    12K citations

  5. University of Wisconsin–Madison

    Madison, United States

    28 h-index

    153 publications

    16.3K citations

  6. University of Pennsylvania

    Philadelphia, United States

    27 h-index

    136 publications

    11.3K citations

  7. Institut Européen de Chimie et Biologie

    Pessac, France

    27 h-index

    155 publications

    8.7K citations

  8. Cornell University

    Ithaca, United States

    26 h-index

    91 publications

    7.9K citations

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Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 144 publications · 19.1K citations

    75

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  2. Journal of Biological Chemistry

    JBC · 179 publications · 14.9K citations

    69

    h-index

  3. Biochemistry

    219 publications · 17.9K citations

    68

    h-index

  4. Journal of the American Chemical Society

    JACS · 174 publications · 14K citations

    66

    h-index

  5. Journal of Molecular Biology

    JMB · 97 publications · 7.6K citations

    51

    h-index

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