Publication | Open Access
Triple Combinations of Lower and Longer Alkyl Gallates and Oxacillin Improve Antibiotic Synergy against Methicillin-Resistant <i>Staphylococcus aureus</i>
23
Citations
8
References
2009
Year
Antibiotic AdjuvantAntimicrobial ChemotherapyLipid MovementAntibiotic ResistanceDrug ResistanceLipid BilayerInfection ControlExternal MediumAntimicrobial ResistanceBiophysicsHealth SciencesAntimicrobial Drug DiscoveryBiochemistryAntimicrobial PharmacokineticsLonger Alkyl GallatesAntimicrobial CompoundPharmacologyBacterial ResistanceClinical MicrobiologyNanodiscAntibioticsLiposome SystemsTriple CombinationsCombination TherapyMicrobiologyAntimicrobial PharmacodynamicsMedicineDrug Discovery
Using liposome systems, we found that gallates with short alkyl chains were located in the external medium and those with longer alkyl chains were located in the surface region of lipid bilayer. Combinations of these gallates remarkably reduced oxacillin MICs against methicillin-resistant Staphylococcus aureus to below the antibiotic breakpoint (< or = 2 microg/ml).
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