In Vitro-to-in Vivo Prediction of P-glycoprotein-Based Drug Interactions at the Human and Rodent Blood-Brain Barrier

Increased drug delivery to the brain by P-glycoprotein inhibition

Abu Sadeque · Clinical Pharmacology & Therapeutics · 2000 · 423 citations

Medicine, Pharmacokinetics, Pharmacology +13

Communication between Multiple Drug Binding Sites on P-glycoprotein

Catherine Martin, G. Berridge, Christopher F. Higgins et al. · Molecular Pharmacology · 2000 · 415 citations

Medicine, Cancer Biology, Pharmacology +16

Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography

Lucy Sasongko, JM Link, Michael Muzi et al. · Clinical Pharmacology & Therapeutics · 2005 · 269 citations

Medicine, Pharmacokinetics, Pharmacology +16

IN VITRO P-GLYCOPROTEIN INHIBITION ASSAYS FOR ASSESSMENT OF CLINICAL DRUG INTERACTION POTENTIAL OF NEW DRUG CANDIDATES: A RECOMMENDATION FOR PROBE SUBSTRATES

Jarkko Rautio, Joan E. Humphreys, Lindsey O. Webster et al. · Drug Metabolism and Disposition · 2006 · 261 citations

Medicine, Pharmacokinetics, Pharmacology +17

Application of Three-Dimensional Quantitative Structure-Activity Relationships of P-Glycoprotein Inhibitors and Substrates

Sean Ekins, Richard B. Kim, Brenda F. Leake et al. · Molecular Pharmacology · 2002 · 185 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17