IN VITRO P-GLYCOPROTEIN INHIBITION ASSAYS FOR ASSESSMENT OF CLINICAL DRUG INTERACTION POTENTIAL OF NEW DRUG CANDIDATES: A RECOMMENDATION FOR PROBE SUBSTRATES

Rational Use of in Vitro P-glycoprotein Assays in Drug Discovery

Joseph W. Polli, Stephen A. Wring, Joan E. Humphreys et al. · Journal of Pharmacology and Experimental Therapeutics · 2001 · 662 citations

Pharmacy, Pharmacokinetics, Pharmacology +14

Passive Permeability and P-Glycoprotein-Mediated Efflux Differentiate Central Nervous System (CNS) and Non-CNS Marketed Drugs

Kelly M. Mahar Doan, Joan E. Humphreys, Lindsey O. Webster et al. · Journal of Pharmacology and Experimental Therapeutics · 2002 · 626 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Positively Cooperative Sites for Drug Transport by P‐Glycoprotein with Distinct Drug Specificities

Adam B. Shapiro, Victor Ling · European Journal of Biochemistry · 1997 · 488 citations

Medicine, Biochemistry, Pharmacology +15

Communication between Multiple Drug Binding Sites on P-glycoprotein

Catherine Martin, G. Berridge, Christopher F. Higgins et al. · Molecular Pharmacology · 2000 · 415 citations

Medicine, Cancer Biology, Pharmacology +16

Inhibition of P-Glycoprotein–Mediated Drug Transport

Martin F. Fromm, Richard B. Kim, C. Michael Stein et al. · Circulation · 1999 · 400 citations

Medicine, Pharmacokinetics, Pharmacology +16