Concepedia

Probe Substrates

Probe Substrate is a selectively employed exogenous compound that serves as a diagnostic agent to identify and quantify the functional activity of specific cytochrome P450 isoforms by exhibiting minimal metabolism by alternative pathways.

294

Publications

18K

Citations

1.6K

Authors

451

Institutions

Publications per year

2017–2026

80

Variants

Probe Substrate

Parents

Publications

294

Enzymatic synthesis of biotin-labeled polynucleotides: novel nucleic acid affinity probes.

Pennina R. Langer, Alex A. Waldrop, David C. Ward · Proceedings of the National Academy of Sciences · 1981 · 1.1K citations · Full text

, , +17

THE CONDUCT OF IN VITRO AND IN VIVO DRUG-DRUG INTERACTION STUDIES: A PHARMACEUTICAL RESEARCH AND MANUFACTURERS OF AMERICA (PhRMA) PERSPECTIVE

Thorir D. Bjornsson, John T. Callaghan, Heidi J. Einolf et al. · Drug Metabolism and Disposition · 2003 · 784 citations

, , +17

Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1

Raimund M. Peter, Ronald Boecker, Philippe Beaune et al. · Chemical Research in Toxicology · 1990 · 535 citations

, , +11

Quantitative Evaluation of the Expression and Activity of Five Major Sulfotransferases (SULTs) in Human Tissues: The SULT “Pie”

Zoe Riches, Emma L. Stanley, Jackie C. Bloomer et al. · Drug Metabolism and Disposition · 2009 · 359 citations · Full text

, , +15

CYP3A4 drug interactions: correlation of 10 <i>in vitro</i> probe substrates

Kenworthy, Bloomer, Houston · British Journal of Clinical Pharmacology · 1999 · 337 citations · Full text

, , +17

1–5 of 294

Authors

1.6K

  1. YU
    Yasuhiro Uno

    Showa Pharmaceutical University, Japan

    5 publications · 93 citations

    5

    h-index

  2. HY
    Hiroshi Yamazaki

    Showa Pharmaceutical University, Japan

    5 publications · 93 citations

    5

    h-index

  3. PM
    Penelope M.Y. Or

    Chinese University of Hong Kong, Hong Kong SAR China

    5 publications · 134 citations

    5

    h-index

  4. HJ
    Heidi J. Einolf

    Novartis (United States), United States

    5 publications · 1.2K citations

    5

    h-index

  5. JH
    John H.K. Yeung

    Chinese University of Hong Kong, Hong Kong SAR China

    5 publications · 134 citations

    5

    h-index

1–5 of 1.6K

Institutions

451

  1. University of Washington

    Seattle, United States

    10 h-index

    60 publications

    3.3K citations

  2. Pfizer (United States)

    New York, United States

    9 h-index

    63 publications

    6K citations

  3. University of Manchester

    Manchester, United Kingdom

    9 h-index

    36 publications

    2.7K citations

  4. Chinese University of Hong Kong

    Hong Kong, Hong Kong

    8 h-index

    32 publications

    1.1K citations

  5. Amgen (United States)

    Thousand Oaks, United States

    7 h-index

    22 publications

    2.8K citations

  6. Eli Lilly (United States)

    Indianapolis, United States

    7 h-index

    57 publications

    3.9K citations

  7. Showa Pharmaceutical University

    Tokyo, Japan

    6 h-index

    25 publications

    603 citations

  8. Chinese Academy of Sciences

    Beijing, China

    6 h-index

    35 publications

    1.2K citations

1–8 of 451

Venues

  1. Drug Metabolism and Disposition

    57 publications · 5.3K citations

    37

    h-index

  2. Xenobiotica

    21 publications · 758 citations

    16

    h-index

  3. Rapid Communications in Mass Spectrometry

    RCM · 9 publications · 568 citations

    9

    h-index

  4. The Journal of Clinical Pharmacology

    9 publications · 612 citations

    9

    h-index

  5. British Journal of Clinical Pharmacology

    BJCP · 8 publications · 874 citations

    8

    h-index

1–5