Application of Three-Dimensional Quantitative Structure-Activity Relationships of P-Glycoprotein Inhibitors and Substrates

SMILES, a chemical language and information system. 1. Introduction to methodology and encoding rules

David Weininger · Journal of Chemical Information and Computer Sciences · 1988 · 7.6K citations

Natural Sciences, Chemistry, Analytical Chemistry +5

Evaluation of Atypical Cytochrome P450 Kinetics with Two-Substrate Models:  Evidence That Multiple Substrates Can Simultaneously Bind to Cytochrome P450 Active Sites

Ken Korzekwa, N. Krishnamachary, Magang Shou et al. · Biochemistry · 1998 · 519 citations

Medicine, Pharmacokinetics, Pharmacology +17

Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.

Erin G. Schuetz, W T Beck, John D. Schuetz · Molecular Pharmacology · 1996 · 498 citations

Medicine, Oncology, Pharmacology +14

Positively Cooperative Sites for Drug Transport by P‐Glycoprotein with Distinct Drug Specificities

Adam B. Shapiro, Victor Ling · European Journal of Biochemistry · 1997 · 488 citations

Medicine, Biochemistry, Pharmacology +15

Interrelationship Between Substrates and Inhibitors of Human CYP3A and P-Glycoprotein

Richard B. Kirn, Christoph Wandel, Brenda F. Leake et al. · Pharmaceutical Research · 1999 · 460 citations

Medicine, Pharmacokinetics, Pharmacology +10