Expression of ADAMTs-5 and TIMP-3 in the condylar cartilage of rats induced by experimentally created osteoarthritis

Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis

S.S. Glasson, Roger Askew, Barbara Sheppard et al. · Nature · 2005 · 1.3K citations

Dentistry, Genetics, Molecular Genetics +14

ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

Heather Stanton, Fraser M. Rogerson, Charlotte J. East et al. · Nature · 2005 · 915 citations

Medicine, Molecular Biology, Orthopaedic Surgery +14

Modified expression of the ADAMTS enzymes and tissue inhibitor of metalloproteinases 3 during human intervertebral disc degeneration

Aneta J. Pockert, Stephen M. Richardson, Christine L. Le Maitre et al. · Arthritis & Rheumatism · 2009 · 270 citations

Life Sciences, Molecular Biology, Pathology +15

Expression of ADAMTS4 (aggrecanase‐1) in human osteoarthritic cartilage

Satoko Naito, Takayuki Shiomi, Aiko Okada et al. · Pathology International · 2007 · 112 citations

Dentistry, Molecular Biology, Orthopaedic Surgery +16

MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein

Michaela Durigova, Hideaki Nagase, John S. Mort et al. · Matrix Biology · 2010 · 74 citations

Life Sciences, Biochemistry, Molecular Biology +3