Metformin reduces endothelial cell expression of both the receptor for advanced glycation end products and lectin-like oxidized receptor 1

Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)

The Lancet · 1998 · 8.3K citations

Medicine, Endocrinology, Pharmacotherapy +17

The Pathobiology of Diabetic Complications

Michael Brownlee · Diabetes · 2005 · 5.3K citations · Full text

Medicine, Biomedical Sciences, Pathobiology +12

Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group.

PubMed · 1998 · 4.3K citations

Medicine, Endocrinology, Pharmacotherapy +17

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

Mark R. Owen, E. Doran, Andrew P. Halestrap · Biochemical Journal · 2000 · 2.1K citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE

Marie‐Paule Wautier, Olivier Chappey, Stefano Corda et al. · American Journal of Physiology-Endocrinology and Metabolism · 2001 · 1.1K citations

Life Sciences, Biochemistry, Cell Biology +17