FEBS Letters · 1996 · 93 citations · 16 references
Life SciencesBiochemistryMolecular BiologyCellular MetabolismRadiation BiophysicsRedox BiochemistryAntioxidant DefenseLipid PeroxidationOxidative Damage To BiomoleculesReactive Oxygen SpeciesUltraviolet Radiation BiologyCellular Redox BalanceCellular Redox SignalingN-acetylcysteine Mechanism Of ActionRadiation-induced Oxidative StressUltraviolet Light ExposureUltraviolet Radiation DamageUltraviolet StressUv Stress Response
UV-A irradiation induces a time-dependent activation of AP-1 in NCTC 2544 human keratinocytes. 4 h after irradiation, a 2-3-fold increase in AP-1 activity is observed in human keratinocytes and fibroblasts. Activation is still detectable 24 h later. The UV-A induced AP-1 binding complex is shown to contain c-Fos and c-Jun proteins. Lipophilic vitamin E impedes UV-A induced lipid peroxidation but does not prevent AP-1 activation which is inhibited by N-acetylcysteine, a hydrophilic antioxidant. This finding suggests that UV-A-dependent AP-1 activation is sensitive to the cellular redox state but is not related to membrane lipid peroxidation.
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Redox activation of Fos‐Jun DNA binding activity is mediated by a DNA repair enzyme.
Steven Xanthoudakis, Graham G. Miao, F. Wang et al. · The EMBO Journal · 1992 · 927 citations · Full text
The mammalian ultraviolet response is triggered by activation of src tyrosine kinases
Yoram Devary, Roberta A. Gottlieb, Tod Smeal et al. · Cell · 1992 · 863 citations