A Reappraisal of the Mechanism by Which Plant Sterols Promote Neutral Sterol Loss in Mice

Abstract

Our data indicate that in mice the cholesterol-lowering effects of PS are to a large extent attributable to stimulation of intestinal, non-bile derived, cholesterol excretion. The Abcg5/Abcg8 heterodimer is involved in facilitating this PS-induced flux of cholesterol.