On the number of steady states in a multiple futile cycle

Construction of a genetic toggle switch in Escherichia coli

Timothy S. Gardner, Charles R. Cantor, James J. Collins · Nature · 2000 · 4.4K citations

Life Sciences, Genetics, Microbiology +13

Ultrasensitivity in the mitogen-activated protein kinase cascade.

Chi‐Ying F. Huang, James E. Ferrell · Proceedings of the National Academy of Sciences · 1996 · 1.2K citations

Life Sciences, Biochemistry, Molecular Biology +16

Detection of multistability, bifurcations, and hysteresis in a large class of biological positive-feedback systems

David Angeli, James E. Ferrell, Eduardo D. Sontag · Proceedings of the National Academy of Sciences · 2004 · 1K citations · Full text

Life Sciences, Cell Biology, Cell Signaling +13

Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades

Nick I. Markevich, Jan B. Hoek, Boris Ν. Kholodenko · The Journal of Cell Biology · 2004 · 722 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Hysteresis drives cell-cycle transitions in <i>Xenopus laevis</i> egg extracts

Wei Sha, Jonathan D. Moore, Katherine Chen et al. · Proceedings of the National Academy of Sciences · 2002 · 512 citations · Full text

Life Sciences, Biology, Cell Biology +17