Influence of Curcumin (<i>Curcuma Longa</i>) as a Natural Anticoccidial Alternative in Adult Rabbits: First Results

Abstract

Coccidiosis is one of the most common ailments in rabbits farming and is usually treated with drugs that can produce resistance; therefore, a natural alternative was sought. The objective of the current study was to evaluate the efficacy of the aqueous extract of curcumin (<em>Curcuma longa</em>) on the excretion of oocysts of Eimeria spp. in New Zealand white rabbits. Twenty-four eight-month-old rabbits were divided into four groups of six animals to be <em>C. longa</em> extract administered at 0 (Control), 10, 25 or 40 mg/kg body weight (BW). Rabbit weights were recorded and faeces samples were collected on d 0, 7, 14, 21, 28, 35 and 42. The McMaster technique was used for quantifying Eimeria spp. oocysts. Results were analysed using multivariate analysis of variance for repeated observations. Statistically significant differences (P&lt;0.05) from d 28 were observed among the Control, the group of 25 mg/kg BW and that of 40 mg/kg BW. At d 42, statistically difference (P&lt;0.05) among the Control group and the other three groups was observed. It could be concluded that <em>C. longa</em> decreased <em>Eimeria</em> spp. oocysts excretion efficiently at a dose of 40 mg/kg BW with 80.1, 63.7 and 64.9% for d 28, 35 and 42, respectively, with reducing concentration of eggs per gram of faeces with about 20.1, 15.6 and 17.8 for d 14, 21 and 35, respectively. However, further studies are needed to assess and confirm the antiparasitic activity of <em>C. longa</em>.