Synthesis and evaluation of aryl thioxothiazolidinone inhibitors of ADAMTS-5 (Aggrecanase-2)

ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

Heather Stanton, Fraser M. Rogerson, Charlotte J. East et al. · Nature · 2005 · 915 citations

Medicine, Molecular Biology, Orthopaedic Surgery +14

Characterization of and osteoarthritis susceptibility in ADAMTS‐4–knockout mice

S.S. Glasson, Roger Askew, Barbara Sheppard et al. · Arthritis & Rheumatism · 2004 · 281 citations

Medicine, Orthopaedic Surgery, Orthopedic Surgery +12

Design and Synthesis of a Series of (2<i>R</i>)-<i>N</i>⁴-Hydroxy-2-(3-hydroxybenzyl)-<i>N</i>- [(1<i>S</i>,2<i>R</i>)-2-hydroxy-2,3-dihydro-1<i>H</i>-inden- 1-yl]butanediamide Derivatives as Potent, Selective, and Orally Bioavailable Aggrecanase Inhibitors

Wenqing Yao, Zelda R. Wasserman, Michael C. Chao et al. · Journal of Medicinal Chemistry · 2001 · 63 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

5-((1H-Pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one inhibitors of ADAMTS-5

A. Gilbert, Matthew G. Bursavich, Sabrina Lombardi et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 59 citations · Full text

Pharmacy, Chemistry, Medicinal Chemistry +6

Synthesis and biological evaluation of biphenylsulfonamide carboxylate aggrecanase-1 inhibitors

Jason Xiang, Yonghan Hu, Thomas S. Rush et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 38 citations · Full text

Pharmacy, Biochemistry, Medicinal Chemistry +10