Erection Capability Is Potentiated by Long-Term Sildenafil Treatment: Role of Blood Flow-Induced Endothelial Nitric-Oxide Synthase Phosphorylation

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

Stefanie Dimmeler, Ingrid Fleming, Beate Fißlthaler et al. · Nature · 1999 · 3.6K citations

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Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

David Fulton, Jean‐Philippe Gratton, Timothy J. McCabe et al. · Nature · 1999 · 2.6K citations

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Nitric Oxide: A Physiologic Mediator of Penile Erection

Arthur L. Burnett, Charles J. Lowenstein, David S. Bredt et al. · Science · 1992 · 1.2K citations

Life Sciences, Neurobiology, Physiology +12

Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction.

Mitra Boolell, Allen Mj, Ballard Sa et al. · PubMed · 1996 · 1.1K citations

Medicine, Pharmacology, Pharmacotherapy +10

Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle

Louis J. Ignarro, Margaret A. Bush, Georgette M. Buga et al. · Biochemical and Biophysical Research Communications · 1990 · 849 citations

Life Sciences, Neuroscience, Physiology +13