Concepedia

PPA250 [3-(2,4-Difluorophenyl)-6-{2-[4-(1 H-imidazol-1-ylmethyl) Phenoxy]ethoxy}-2-phenylpyridine], a Novel Orally Effective Inhibitor of the Dimerization of Inducible Nitric-Oxide Synthase, Exhibits an Anti-Inflammatory Effect in Animal Models of Chronic Arthritis

M. Ohtsuka, Fujiko Konno, Haruyoshi Honda, Takayuki Oikawa, Masago Ishikawa, Nobuhisa Iwase, Kazuo Isomae, Fumio Ishii, Hiromichi Hemmi, Susumu Satô

Journal of Pharmacology and Experimental Therapeutics · 2002 · 39 citations · 34 references

DOI

Concepts

References

34

Localization of nitric oxide synthase indicating a neural role for nitric oxide

David S. Bredt, Paul M. Hwang, Solomon H. Snyder · Nature · 1990 · 3K citations

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L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells.

John B. Hibbs, Zdenek Vavrin, Read R. Taintor · The Journal of Immunology · 1987 · 937 citations · Full text

, , +13

Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases.

A J Farrell, David R. Blake, Richard Palmer et al. · Annals of the Rheumatic Diseases · 1992 · 721 citations

, , +15

Suppression of arthritis by an inhibitor of nitric oxide synthase.

Nancy McCartney‐Francis, J B Allen, Diane Mizel et al. · The Journal of Experimental Medicine · 1993 · 651 citations · Full text

, , +17

Nitrogen Oxide Levels in Patients After Trauma and During Sepsis

Juan B. Ochoa, Anthony O. Udekwu, Timothy R. Billiar et al. · Annals of Surgery · 1991 · 605 citations

, , +15