Concepedia

Clicking 1,2,4,5-tetrazine and cyclooctynes with tunable reaction rates

Weixuan Chen, Danzhu Wang, Chaofeng Dai, Donald Hamelberg, Binghe Wang

Chemical Communications · 2011 · 202 citations · 22 references

DOI

Concepts

Abstract

Substituted tetrazines have been found to undergo facile inverse electron demand Diels-Alder reactions with "tunable" reaction rates.

References

22

A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes

Vsevolod V. Rostovtsev, Luke G. Green, Valery V. Fokin et al. · Angewandte Chemie International Edition · 2002 · 11.5K citations

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Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality

Ellen M. Sletten, Carolyn R. Bertozzi · Angewandte Chemie International Edition · 2009 · 3.1K citations · Full text

, , +5

Cell Surface Engineering by a Modified Staudinger Reaction

Eliana Saxon, Carolyn R. Bertozzi · Science · 2000 · 2.4K citations

, , +17

Tetrazine Ligation: Fast Bioconjugation Based on Inverse-Electron-Demand Diels−Alder Reactivity

Melissa L. Blackman, Maksim Royzen, Joseph M. Fox · Journal of the American Chemical Society · 2008 · 1.6K citations · Full text

, , +12

In Vivo Imaging of Membrane-Associated Glycans in Developing Zebrafish

Scott T. Laughlin, Jeremy M. Baskin, Sharon L. Amacher et al. · Science · 2008 · 1K citations · Full text

, , +17