Transient Receptor Potential Vanilloid 4 Activation Constricts the Human Bronchus via the Release of Cysteinyl Leukotrienes

A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

Dongeun Huh, Daniel C. Leslie, Benjamin D. Matthews et al. · Science Translational Medicine · 2012 · 988 citations · Full text

Pharmacy, Pharmacology, Toxicology +17

Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4

Joris Vriens, Hiroyuki Watanabe, Annelies Janssens et al. · Proceedings of the National Academy of Sciences · 2003 · 634 citations · Full text

Life Sciences, Pharmacology, Physiology +17

An Orally Active TRPV4 Channel Blocker Prevents and Resolves Pulmonary Edema Induced by Heart Failure

Kevin S. Thorneloe, Mui Cheung, Weike Bao et al. · Science Translational Medicine · 2012 · 336 citations

Medicine, Cardiology, Pharmacotherapy +10

Systemic Activation of the Transient Receptor Potential Vanilloid Subtype 4 Channel Causes Endothelial Failure and Circulatory Collapse: Part 2

Robert N. Willette, Weike Bao, Sandhya S. Nerurkar et al. · Journal of Pharmacology and Experimental Therapeutics · 2008 · 295 citations

Life Sciences, Pharmacology, Physiology +17

Functional expression of transient receptor potential melastatin- and vanilloid-related channels in pulmonary arterial and aortic smooth muscle

Xiao-Ru Yang, Mo‐Jun Lin, Lionel S. McIntosh et al. · American Journal of Physiology-Lung Cellular and Molecular Physiology · 2006 · 274 citations

Life Sciences, Pharmacology, Physiology +17