PubMed · 2014 · 155 citations · 42 references
Life SciencesBioinformaticsBiologyGene ExpressionGene Regulatory NetworksMachine LearningBiological NetworksGraph-based LearningNetwork InferenceNetwork ModelingRegulatory Network InferenceAlternating Direction Method Of MultipliersConditional Dependence EstimationGaussian Graphical ModelsGene Regulatory Network ModelsGraphical ModelsHub NodesTranscriptional Regulation NetworksTranscriptional Regulatory Networks
penalty function, we formulate two convex optimization problems that correspond to these two assumptions. We solve these problems using an alternating direction method of multipliers algorithm, and we derive a set of necessary and sufficient conditions that allows us to decompose the problem into independent subproblems so that our algorithm can be scaled to high-dimensional settings. Our proposal is illustrated on synthetic data, a webpage data set, and a brain cancer gene expression data set.
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Roel G.W. Verhaak, Katherine A. Hoadley, Elizabeth Purdom et al. · Cancer Cell · 2010 · 7.7K citations · Full text
The Adaptive Lasso and Its Oracle Properties
Hui Zou · Journal of the American Statistical Association · 2006 · 7.6K citations