Concepedia

Dual inhibition of SRC and Aurora kinases induces postmitotic attachment defects and cell death

Vladimir Ratushny, Harsh B. Pathak, Neil Beeharry, Nadezhda Tikhmyanova, Fang Xiao, T Li, Samuel Litwin, Denise C. Connolly, Tim J. Yen, Louis M. Weiner,

Oncogene · 2011 · 31 citations · 35 references

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35

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

Ting‐Chao Chou, Paul Talalay · Advances in Enzyme Regulation · 1984 · 7.2K citations

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Dasatinib versus Imatinib in Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia

Hagop M. Kantarjian, Neil P. Shah, Andreas Hochhaus et al. · New England Journal of Medicine · 2010 · 1.6K citations

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Discovery of <i>N</i>-(2-Chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a Dual Src/Abl Kinase Inhibitor with Potent Antitumor Activity in Preclinical Assays

Louis J. Lombardo, Francis Y. Lee, Ping Chen et al. · Journal of Medicinal Chemistry · 2004 · 1.3K citations · Full text

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A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

James R. Bischoff · The EMBO Journal · 1998 · 1.2K citations · Full text

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Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

Claire Ditchfield, Victoria Johnson, Anthony Tighe et al. · The Journal of Cell Biology · 2003 · 1.2K citations · Full text

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