5-Lipoxygenase Deficiency Reduces Hepatic Inflammation and Tumor Necrosis Factor α–Induced Hepatocyte Damage in Hyperlipidemia-Prone Apoe-Null Mice

Abstract

These combined data indicate that hyperlipidemic mice lacking 5-LO are protected against hepatic inflammatory injury, suggesting that 5-LO is involved in mounting hepatic inflammation in metabolic disease.